UJI AKTIVITAS ANTIJAMUR SEDIAAN SABUN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DAN RIMPANG JAHE (Zingiber Officinale) TERHADAP Candida albicans

Hana, Putriana (2026) UJI AKTIVITAS ANTIJAMUR SEDIAAN SABUN EKSTRAK ETANOL DAUN SIRIH (Piper betle L.) DAN RIMPANG JAHE (Zingiber Officinale) TERHADAP Candida albicans. Diploma thesis, UIN RADEN INTAN LAMPUNG.

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Abstract

ABSTRAK Penelitian ini bertujuan mengevaluasi aktivitas antijamur sabun dengan ekstrak etanol daun sirih (Piper betle L.) dan rimpang jahe (Zingiber officinale) terhadap Candida albicans ATCC-14053 sebagai alternatif terapi konvensional. Penelitian dilakukan secara eksperimental dengan metode difusi sumuran menggunakan 24 sampel yang dibagi menjadi enam kelompok, terdiri atas empat variasi konsentrasi ekstrak (5%:5%, 2,5%:7,5%, 7,5%:2,5%, dan 10%:10%), kontrol positif (ketoconazole), serta kontrol negatif (basis sabun). Evaluasi fisik meliputi uji pH, tinggi busa, homogenitas, dan iritasi, dan seluruh sediaan memenuhi standar persyaratan. Hasil menunjukkan bahwa konsentrasi 10%:10% memberikan zona hambat terbesar (13,7 mm; kategori kuat), sedangkan konsentrasi 2,5%:7,5% memberikan zona hambat terkecil (7,6 mm; kategori sedang). Analisis data menggunakan One-Way ANOVA menghasilkan nilai p < 0,05, yang menunjukkan adanya perbedaan signifikan antar kelompok perlakuan. Berdasarkan hasil dapat disimpulkan bahwa sabun ekstrak etanol daun sirih dan rimpang jahe memiliki aktivitas antijamur yang signifikan terhadap Candida albicans dan berpotensi dikembangkan sebagai alternatif pengobatan infeksi jamur. Kata kunci: Piper betle L., Zingiber officinale, antijamur, difusi sumuran, Candida albicans ATCC-14053. ABSTRACT This study aimed to evaluate the antifungal activity of soap formulations containing ethanol extracts of betel leaves (Piper betle L.) and ginger rhizomes (Zingiber officinale) against C. albicans ATCC-14053 as an alternative to conventional therapy. The research was conducted experimentally using the well diffusion method on 24 samples divided into six groups, consisting of four extract concentration variations (5%:5%, 2.5%:7.5%, 7.5%:2.5%, and 10%:10%), a positive control (ketoconazole), and a negative control (soap base). Physical evaluations included pH, foam height, homogeneity, and irritation tests, all of which met the required standards. The results showed that the 10%:10% concentration produced the largest inhibition zone (13.7 mm; strong category), while the 2.5%:7.5% concentration produced the smallest inhibition zone (7.6 mm; moderate category). Data analysis using One-Way ANOVA obtained a p-value < 0.05, indicating significant differences among the treatment groups. Based on these findings, it can be concluded that soap formulations containing ethanol extracts of betel leaves and ginger rhizomes exhibit significant antifungal activity against C. albicans and have potential to be developed as an alternative treatment for fungal infections. Keywords: Piper betle L., Zingiber officinale, antifungal, well diffusion, Candida albicans ATCC-14053.

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